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ENMD-2076 tartrate
CAS No. 1291074-87-7
ENMD-2076 tartrate( ENMD 2076 | ENMD2076 )
Catalog No. M11180 CAS No. 1291074-87-7
A multitargeted kinase inhibitor with IC50s of 3/14/23/40 nM for Flt3/Aurora A/Src/VEGFR2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 171 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameENMD-2076 tartrate
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NoteResearch use only, not for human use.
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Brief DescriptionA multitargeted kinase inhibitor with IC50s of 3/14/23/40 nM for Flt3/Aurora A/Src/VEGFR2.
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DescriptionA multitargeted kinase inhibitor with IC50s of 3/14/23/40 nM for Flt3/Aurora A/Src/VEGFR2; also inhibits Aurora B, c-Kit, FGFR1 (IC50=100-350 nM); orally bioactive.Liver CancerPhase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsENMD 2076 | ENMD2076
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PathwayCell Cycle/DNA Damage
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TargetAurora Kinase
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RecptorFLT3 , RET , Aurora A , VEGFR3/FLT4 , Src
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Research AreaCancer
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IndicationLiver Cancer
Chemical Information
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CAS Number1291074-87-7
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Formula Weight525.5569
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Molecular FormulaC25H31N7O6
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC1=CC(NC2=NC(/C=C/C3=CC=CC=C3)=NC(N4CCN(C)CC4)=C2)=NN1.OC(C(C(O)=O)O)C(O)=O
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Chemical Name4-Pyrimidinamine, 6-(4-methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(1E)-2-phenylethenyl]- Tartrate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tentler JJ, et al. Clin Cancer Res. 2010 Jun 1;16(11):2989-98.
2. Matulonis UA, et al. Eur J Cancer. 2013 Jan;49(1):121-31.
3. Fletcher GC, et al. Mol Cancer Ther. 2011 Jan;10(1):126-37.
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